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- Hormone Panels
- Estradiol
- Estriol
- Estrone
- Progesterone
- Testosterone
- DHEA
- Cortisol
- Melatonin
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ESTRIOL
Estriol is one of the three major naturally occurring estrogens, the others being estradiol and estrone. Estriol is produced almost exclusively during pregnancy and is the major estrogen produced in the normal human fetus. During pregnancy the production of estriol depends on an intact maternal-placental-fetal unit. Fetal-placental production of estriol leads to a progressive rise in maternal circulating levels reaching a late-gestational peak several orders of magnitude greater than non-pregnant levels. Estriol has been suggested to be less carcinogenic than estradiol and estrone in animal studies. It has been shown that at doses effective for the relief of postmenopausal symptoms, estriol does not induce endometrial proliferation to the extent of the other estrogens. Topical estriol has also been used for the relief of postmenopausal genital atrophic changes and urinary incontinence.
Interpretation of Results
High levels of estriol are seen in gestation. Otherwise the production of estriol is uniformly low regardless of menopausal status or gender. Estriol is measured in pg/ml.
| Endogenous |
Supplemented |
| Premenopausal 4.4 - 8.3 |
Oral Replacement* 20 - 40 |
| Postmenopausal 3.0 - 11.8 |
Transdermal Cream* 300 - 500 |
| Men 4.7 - 7.1 |
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*Ranges represent levels 8 - 12 hours after last dose or application
- Menopause Panel - Basic
- The Menopause Profile measures Estradiol, Progesterone, Testosterone, and DHEA. The Menopause Profile is recommended for peri or postmenopausal women experiencing hormone-related problems, including: mood changes, hot flashes, heavy menses, weight gain, low libido, insomnia, headaches, fatigue, bone loss, hair loss, or difficulty concentrating.
- Menopause Panel - Extended
- The Menopause Panel - Extended measures Estrone, Estradiol, Estriol, Progesterone, Testosterone, and DHEA. It is the same as the Menopausal-Basic Panel, plus Estriol, and Estrone. The Menopause Panel - Extended is recommended for peri and post menopausal women that are currently using estriol or estrone (Hormone Replacement Therapy). This test can also be used to monitor breast cancer risk. Several epidemiological studies have shown that women who have an increased amount of estriol in relation to estradiol and estrone, have a decreased risk of developing breast cancer.
- Cycling Female Panel - Basic
- The Cycling Female Panel - Basic measures Estradiol, Progesterone, and DHEA. The Cycling Female Panel - Basic is recommended for premenopausal women with hormone troubles possibly related to progesterone deficiency or estrogen excess. Symptoms would include: PMS, mood changes, cramping, irritability, uterine fibroids, fibrocystic breasts, weight gain, headaches/migraines, heavy menses, fatigue, and low libido.
- Cycling Female Panel - Extended
- The Cycling Female Panel - Extended measures Estradiol and Progesterone five times over a one month period, and Testosterone. Test results are reported graphically so peaks and depressions can be easily identified. The Cycling Female Panel - Extended is designed to uncover more complex problems associated with hormone imbalance among cycling females.
References
- Buster JE: Gestational changes in steroid hormone biosynthesis, secretion, metabolism, and action. Clin Perinatol 1983;10:527-552
- Canez MS, Lee KH, Olive DL: Progestogens and estrogens. Infertil Reproduct Med Clin North Amer 1992;3:59-78
- Yang TS, Tsan SH, Chang SP, Ng Ht: Efficacy and safety of estriol replacement therapy for climacteric women. Am J Obstet Gynecol 1995;173:670-671
- Lemon HM, Kumar PF, Peterson C, Rodriquez-Sierra JF, Abbo KM: Inhibition of radiogenic mammary carcinoma in rats by estriol or tamoxifen. Cancer 1989;63:1685-1692
- McGregor JA, Jackson GM, Lachelin GGL et al.: Salivary Estriol as Risk Assessment for Preterm Labor: A Prospective Trial. Am J Obstet Gynecol 1995;173(4);1337-1342
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