ESTRONE
Estrone is one of the three naturally occurring estrogens, the others being estradiol and estriol. Estrone is produced primarily from androstenedione originating from the gonads or the adrenal cortex. In premenopausal women, more than 50% of the estrone is secreted by the ovaries. In prepubertal children, men and non-supplemented postmenopausal women the major portion of estrone is derived from peripheral tissue conversion of androstenedione. Interconversion of estrone and estradiol also occurs in peripheral tissue. Bioassay data indicate that the estrogenic action is much less than estradiol. Estrone is a primary estrogenic component of several pharmaceutical preparations, including those containing conjugated and esterified estrogens. In premenopausal women estrone levels generally parallel those of estradiol. After menopause estrone levels increase, possibly due to increased conversion of androstenedione to estrone.
Interpretation of Results
Salivary levels of naturally produced hormones reflect the free fraction (non-protein bound fraction) of the hormone in the blood. Levels are about 1- 8% of the total serum concentration (although individual variability is relatively broad). Salivary levels of those on oral replacement show the same pattern. Trough levels are just prior to next scheduled dose and were used to determine our ranges.
Normal range of estrone in saliva without supplementation.
Female: 0.5 - 4.5 pg/mlMale: 0.5 - 3.9 pg/ml
Contact North Bay Diagnostics at 888-689-TST (8378) to order your lab kit.
- Custom Hormone Panel
- Test Estrone
- $47.00
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- Menopause Panel - Basic
- The Menopause Profile measures Estradiol, Progesterone, Testosterone, and DHEA. The Menopause Profile is recommended for peri or postmenopausal women experiencing hormone-related problems, including: mood changes, hot flashes, heavy menses, weight gain, low libido, insomnia, headaches, fatigue, bone loss, hair loss, or difficulty concentrating.
- $151.00
- Menopause Panel - Extended
- The Menopause Panel - Extended measures Estrone, Estradiol, Estriol, Progesterone, Testosterone, and DHEA. It is the same as the Menopausal-Basic Panel, plus Estriol, and Estrone. The Menopause Panel - Extended is recommended for peri and post menopausal women that are currently using estriol or estrone (Hormone Replacement Therapy). This test can also be used to monitor breast cancer risk. Several epidemiological studies have shown that women who have an increased amount of estriol in relation to estradiol and estrone, have a decreased risk of developing breast cancer.
- $207.00
- Cycling Female Panel - Basic
- The Cycling Female Panel - Basic measures Estradiol, Progesterone, and DHEA. The Cycling Female Panel - Basic is recommended for premenopausal women with hormone troubles possibly related to progesterone deficiency or estrogen excess. Symptoms would include: PMS, mood changes, cramping, irritability, uterine fibroids, fibrocystic breasts, weight gain, headaches/migraines, heavy menses, fatigue, and low libido.
- $120.00
- Cycling Female Panel - Extended
- The Cycling Female Panel - Extended measures Estradiol and Progesterone five times over a one month period, and Testosterone. Test results are reported graphically so peaks and depressions can be easily identified. The Cycling Female Panel - Extended is designed to uncover more complex problems associated with hormone imbalance among cycling females.
- $331.00
References
- Baird DT, Fraser IS: Blood production and ovarian secretion rates of estradiol - 17B and estrone in women throughout the menstrual cycle. J Clin Endocrinol Metab 1974;38:1009
- Grodin JM, Siiteri PK, MacDonald PC: Source of estrogen production in postmenopausal women. J Clin Endocrinal Metab 1973;26:207
- Longcope C: The endocrinology of the menopause. In: Treatment of the Postmenopausal Woman. Lobo RA, ed., Raven Press, New York, NY 1993:47
- Lobo RA: Treatment of the postmenopausal woman: Where we are today. In: Treatment of the Postmenopausal Woman. Lobo RA, ed., Raven Press, New York, NY 1993:47
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